Niveles plasmáticos de la hormona antimülleriana y su relación con la población folicular en hembras Brahman
Palabras clave:
folículos, niveles plasmáticos, HAM, cuerpo lúteo, reproducción
Resumen
La hormona antimülleriana (HAM) funciona como un modulador del desarrollo folicular y su nivel plasmático es independiente de la etapa del ciclo estral. Dado que la diferencia en la población folicular dentro y entre razas, es un factor a considerar en la biotecnología reproductiva, se considera que el nivel plasmático de HAM es una herramienta útil para seleccionar donantes de embriones. Con la finalidad de determinar la relación entre los niveles plasmáticos de HAM y la población folicular en hembras Brahman, se seleccionaron al azar 60 individuos entre 18 y 132 meses de edad, en el cantón Paján, provincia de Manabí, Ecuador. Se utilizó un diseño experimental completamente aleatorizado con arreglo factorial de los tratamientos. El factor A correspondió a la categoría del animal (vacas y vaquillas) y el factor B correspondió a los niveles de HAM (100-200; 200-300 y más de 300 pg.mL-1) con diez repeticiones. Se realizaron análisis estadístico descriptivo, análisis de varianza y ajustes de regresión. Se observó mayor número de folículos pequeños, grandes y totales a medida que aumentaron los niveles de HAM, los cuales fueron explicados a través de un ajuste cuadrático positivo, cuyo máximo fue alcanzado alrededor de 756 pg.mL-1. A partir de ese nivel ocurrió el descenso en la población de folículos. Los niveles plasmáticos de HAM representaron un indicador confiable de la población de folículos y un biomarcador para predecir el potencial reproductivo de la hembra Brahman.
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• Baldrighi, JM; Sá Filho, MF; Batista, EO; Lopes, RN; Visintin, JA; Baruselli, PS; Assumção, ME. 2014. Anti-Müllerian hormone concentration and antral ovarian follicle population in murrah heifers compared to holstein and gyr kept under the same management. Reproduction in Domestic Animals 49:1015-1020.
• Ball B. 2011. Embryonic loss. Equine reproduction, Volume 2:2327-2338.
• Batista, EO; Guerreiro, BM; Freitas, BG; Silva, JC; Vieira, L; Ferreira, RM; Rezende, RG; Basso, AC; Lopes, RN; Rennó, FP; Souza, AH; Baruselli, PS. 2016. Plasma anti-Müllerian hormone as a predictive endocrine marker to select Bos taurus (Holstein) and Bos indicus (Nelore) calves for in vitro embryo production. Domestic animal endocrinology 54:1-9.
• Bhide, P; Homburg, R. 2016. Anti-Müllerian hormone and polycystic ovary syndrome. Best Practice & Research: Clinical Obstetrics & Gynaecology 37:38-45.
• Borges, AM; Torres,CA; Ruas, JR; Jr Rocha, VR; Carvalho, GR. 2001. Dinámica folicular ovariana em novilhas mestiças Holandês-Zebu. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 53(5):595-604.
• Broekmans, FJ; Visser, JA; Laven, JS; Broer, SL; Themmen, AP; Fauser, BC. 2008. Anti-Müllerian hormone and ovarian dysfunction. Trends in Endocrinology & Metabolism 19(9):340-347.
• Del Río Avilés, AD; Nieto Villanueva, E; Sánchez Castro, MÁ; Zamorano Algandar, R; Torres Simental, JF; Méndez Castillo, MG; Acosta Bauza, S; Torres Garaygordobil, A; Luna Nevárez, P. 2017. La hormona anti-mulleriana como un marcador endócrino asociado a la fertilidad postparto en Vacas Holstein. La Sociedad Académica 49:50-56.
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• Durlinger, AL; Gruijters, MJ; Kramer, P; Karels, B; Ingraham, HA; Nachtigal, MW; Uilenbroek, JT; Grootegoed, JA; Themmen, AP. 2002. Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 143(3):1076-1084.
• García-Guerra, A; Motta, JC; Melo, LF; Kirkpatrick, BW; Wiltbank, MC. 2017. Ovulation rate, antral follicle count, and circulating anti-Müllerian hormone in Trio allele carriers, a novel high fecundity bovine genotype. Theriogenology 101:81-90.
• Gimenes, LU; Ferraz, ML; Fantinato-Neto, P; Chiaratti, MR; Mesquita, LG; Sá Filho, MF; Meirelles, FV; Trinca, LA; Rennó, FP; Watanabe, YF; Baruselli, PS. 2015. The interval between the emergence of pharmacologically synchronized ovarian follicular waves and ovum pickup does not significantly affect in vitro embryo production in Bos indicus, Bos taurus, and Bubalus bubalis. Theriogenology 83(3):385–393.
• Gobikrushanth, M; Dutra, PA; Bruinje, TC; Colazo, MG; Butler, ST; Ambrose, DJ. 2017. Repeatability of antral follicle counts and anti-Mullerian hormone and their associations determined at an unknown stage of follicular growth and an expected day of follicular wave emergence in dairy cows. Theriogenology 92:90–94.
• Guerreiro, BM; Batista, EO; Vieira, LM; Sá Filho, MF; Rodrigues, CA; Castro Netto, A; Silveira, CR; Bayeux, BM; Dias, EA; Monteiro, FM; Accorsi, M; Lopes, RN; Baruselli, PS. 2014. Plasma anti-mullerian hormone: an endocrine marker forin vitro embryo production from Bos taurus and Bos indicus donors. Domestic animal endocrinology 49:96–104.
• Hernández, CJ. 2012. Fisiología clínica de la reproducción de bovinos lecheros. Desarrollo folicular. Delegación Coyoacán México D.F. pp. 20-24.
• Ireland, JJ; Smith, GW; Scheetz, D; Jimenez-Krassel, F; Folger, JK; Ireland, JL; Mossa, F; Lonergan, P; Evans, AC. 2011. Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Müllerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle. Reproduction, Fertility and Development 23(1):1-14.
• Ireland, JJ; Ward, F; Jimenez-Krassel, F; Ireland, JL; Smith, GW; Lonergan, P; Evans, AC. 2007. Follicle numbers are highly repeatable within individual animals but are inversely correlated with FSH concentrations and the proportion of good-quality embryos after ovarian stimulation in cattle. Human Reproduction 22(6):1687-1695.
• Ireland, JJ; Zielak-Steciwko, AE; Jimenez-Krassel, F; Folger, J; Bettegowda, A; Scheetz, D; Walsh, S; Mossa, F; Knight, PG; Smith, GW; Lonergan, P; Evans, AC. 2009. Variation in the ovarian reserve is linked to alterations in intrafollicular estradiol production and ovarian biomarkers of follicular differentiation and oocyte quality in cattle. Biology of Reproduction 80(5):954-964.
• Ireland, JL; Scheetz, D; Jimenez-Krassel, F; Themmen, AP; Ward, F; Lonergan, P; Smith, GW; Perez, GI; Evans, AC; Ireland, JJ. 2008. Antral follicle count reliably predicts number of morphologically healthy oocytes and follicles in ovaries of young adult cattle. Biology of Reproduction 79(6):1219-1225.
• Jimenez-Krassel, F; Scheetz, DM; Neuder, LM; Ireland, JL; Pursley, JR; Smith, GW; Tempelman, RJ; Ferris, T; Roudebush, WE; Mossa, F; Lonergan, P; Evans, AC; Ireland, JJ. 2015. Concentration of anti-Müllerian hormone in dairy heifers is positively associated with productive herd life. Journal of Dairy Science 98(5):3036-3045.
• Koizumi, M; Kadokawa, H. 2017. Positive correlations of age and parity with plasma anti-Müllerian hormone concentrations in Japanese Black cows. The Journal of Reproduction and Development 63(2):205-209.
• Liang, A; Salzano, A; D’Esposito, M; Comin, A; Montillo, M; Yang, L; Campanile, G; Gasparrini, B. 2016. Anti-Mullerian hormone (AMH) concentration in follicular fluid and mRNA expression of AMH receptor type II and LH receptor in granulosa cells as predictive markers of good buffalo (Bubalus bubalis) donors. Theriogenology. 86(4):963-970.
• Monniaux, D; Barbey, S; Rico, C; Fabre, S; Gallard, Y; Larroque, H. 2010. Anti-Müllerian hormone: a predictive marker of embryo production in cattle? Reproduction, Fertility and Development 22(7):1083-1091.
• Monniaux, D; Di Clemente, N; Touzé, Jl; Belville, C; Rico, C; Bontoux, M; Picard, JY; Fabre, S. 2008. Intrafollicular steroids and Anti-Müllerian hormone during normal and cystic ovarian follicular development in the cow. Biology of Reproduction 79(2):387-396.
• Monniaux, D; Drouilhet, L; Rico, C; Estienne, A; Jarrier, P; Touzé, J; Sapa,J; Phocas, F; Dupont, J; Dalbiès-Tran, R; Fabre, S. 2012. Regulation of anti-Mullerian hormone production in domestic animals. Reproduction, Fertility and Development 25(1):1-16.
• Mossa, F; Jimenez-Krassel, F; Folger, JK; Ireland, JL; Smith, GW; Lonergan, P; Evans, AC; Ireland, JJ. 2010. Evidence that high variation in antral follicle count during follicular waves is linked to alterations in ovarian androgen production in cattle. Reproduction 140(5):713-720
• Pfeiffer, KE; Jury, LJ; Larson, JE. 2014. Determination of anti-Müllerian hormone at estrus during a synchronized and a natural bovine estrous cycle. Domestic Animal Endocrinology 46:58-64.
• Ribeiro, ES; Bisinotto, RS; Lima, FS; Greco, LF; Morrison, A; Kumar, A; Thatcher, WW; Santos, JE. 2014. Plasma anti-Müllerian hormone in adult dairy cows and associations with fertility. Journal of Dairy Science 97(11):6888-6900
• Rico, C; Drouilhet, L; Salvetti, P; Dalbiès-Tran, R; Jarrier, P; Touzé, JL; Pillet, E; Ponsart, C; Fabre, S; Monniaux, D. 2012. Determination of anti-Müllerian hormone concentrations in blood as a tool to select Holstein donor cows for embryo production: from the laboratory to the farm. Reproduction, Fertility and Development 24(7):932-944.
• Rico, C; Fabre, S; Médigue, C; di Clemente, N; Clément, F; Bontoux, M; Touzé, JL; Dupont, M; Briant, E; Rémy, B; Beckers, JF; Monniaux, D. 2009. Anti-Müllerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow. Biology of Reproduction 80(1):50-59.
• Rico, C; Médigue, C; Fabre, S; Jarrier, P; Bontoux, M; Clément, F; Monniaux, D. 2011. Regulation of anti-Müllerian hormone production in the cow: a multiscale study at endocrine, ovarian, follicular, and granulosa cell levels. Biology of Reproduction 84(3):560-571.
• Rojas-García, PP; Recabarren, MP; Palma, S; Maliqueo, M; Carrasco, A; Sir-Petermann, T; Recabarren, SE. 2014. Morfometría ovárica y expresión del ARN mensajero de hormona antimülleriana (AMH), receptor de FSH (FSHR) y factor nuclear kappa B (NFkB) en folículos en crecimiento de borregas expuestas prenatalmente a testosterona. Archivos de Medicina Veterinaria 46(1):13-21.
• Santa Cruz, R; Cushman, RA; Viñoles, C. 2018. Antral follicular count is a tool that may allow the selection of more precocious Bradford heifers at weaning. Theriogenology 119:35-42.
• Baldrighi, JM; Sá Filho, MF; Batista, EO; Lopes, RN; Visintin, JA; Baruselli, PS; Assumção, ME. 2014. Anti-Müllerian hormone concentration and antral ovarian follicle population in murrah heifers compared to holstein and gyr kept under the same management. Reproduction in Domestic Animals 49:1015-1020.
• Ball B. 2011. Embryonic loss. Equine reproduction, Volume 2:2327-2338.
• Batista, EO; Guerreiro, BM; Freitas, BG; Silva, JC; Vieira, L; Ferreira, RM; Rezende, RG; Basso, AC; Lopes, RN; Rennó, FP; Souza, AH; Baruselli, PS. 2016. Plasma anti-Müllerian hormone as a predictive endocrine marker to select Bos taurus (Holstein) and Bos indicus (Nelore) calves for in vitro embryo production. Domestic animal endocrinology 54:1-9.
• Bhide, P; Homburg, R. 2016. Anti-Müllerian hormone and polycystic ovary syndrome. Best Practice & Research: Clinical Obstetrics & Gynaecology 37:38-45.
• Borges, AM; Torres,CA; Ruas, JR; Jr Rocha, VR; Carvalho, GR. 2001. Dinámica folicular ovariana em novilhas mestiças Holandês-Zebu. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 53(5):595-604.
• Broekmans, FJ; Visser, JA; Laven, JS; Broer, SL; Themmen, AP; Fauser, BC. 2008. Anti-Müllerian hormone and ovarian dysfunction. Trends in Endocrinology & Metabolism 19(9):340-347.
• Del Río Avilés, AD; Nieto Villanueva, E; Sánchez Castro, MÁ; Zamorano Algandar, R; Torres Simental, JF; Méndez Castillo, MG; Acosta Bauza, S; Torres Garaygordobil, A; Luna Nevárez, P. 2017. La hormona anti-mulleriana como un marcador endócrino asociado a la fertilidad postparto en Vacas Holstein. La Sociedad Académica 49:50-56.
• Di Rienzo, JA; Casanoves,F; Balzarini, M; González, L; Tablada, M; Robledo,V. 2017. InfoStat versión 2017. Grupo InfoStat, FCA, Universidad Nacional de Córdoba, Argentina.
• Durlinger, AL; Gruijters, MJ; Kramer, P; Karels, B; Ingraham, HA; Nachtigal, MW; Uilenbroek, JT; Grootegoed, JA; Themmen, AP. 2002. Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 143(3):1076-1084.
• García-Guerra, A; Motta, JC; Melo, LF; Kirkpatrick, BW; Wiltbank, MC. 2017. Ovulation rate, antral follicle count, and circulating anti-Müllerian hormone in Trio allele carriers, a novel high fecundity bovine genotype. Theriogenology 101:81-90.
• Gimenes, LU; Ferraz, ML; Fantinato-Neto, P; Chiaratti, MR; Mesquita, LG; Sá Filho, MF; Meirelles, FV; Trinca, LA; Rennó, FP; Watanabe, YF; Baruselli, PS. 2015. The interval between the emergence of pharmacologically synchronized ovarian follicular waves and ovum pickup does not significantly affect in vitro embryo production in Bos indicus, Bos taurus, and Bubalus bubalis. Theriogenology 83(3):385–393.
• Gobikrushanth, M; Dutra, PA; Bruinje, TC; Colazo, MG; Butler, ST; Ambrose, DJ. 2017. Repeatability of antral follicle counts and anti-Mullerian hormone and their associations determined at an unknown stage of follicular growth and an expected day of follicular wave emergence in dairy cows. Theriogenology 92:90–94.
• Guerreiro, BM; Batista, EO; Vieira, LM; Sá Filho, MF; Rodrigues, CA; Castro Netto, A; Silveira, CR; Bayeux, BM; Dias, EA; Monteiro, FM; Accorsi, M; Lopes, RN; Baruselli, PS. 2014. Plasma anti-mullerian hormone: an endocrine marker forin vitro embryo production from Bos taurus and Bos indicus donors. Domestic animal endocrinology 49:96–104.
• Hernández, CJ. 2012. Fisiología clínica de la reproducción de bovinos lecheros. Desarrollo folicular. Delegación Coyoacán México D.F. pp. 20-24.
• Ireland, JJ; Smith, GW; Scheetz, D; Jimenez-Krassel, F; Folger, JK; Ireland, JL; Mossa, F; Lonergan, P; Evans, AC. 2011. Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Müllerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle. Reproduction, Fertility and Development 23(1):1-14.
• Ireland, JJ; Ward, F; Jimenez-Krassel, F; Ireland, JL; Smith, GW; Lonergan, P; Evans, AC. 2007. Follicle numbers are highly repeatable within individual animals but are inversely correlated with FSH concentrations and the proportion of good-quality embryos after ovarian stimulation in cattle. Human Reproduction 22(6):1687-1695.
• Ireland, JJ; Zielak-Steciwko, AE; Jimenez-Krassel, F; Folger, J; Bettegowda, A; Scheetz, D; Walsh, S; Mossa, F; Knight, PG; Smith, GW; Lonergan, P; Evans, AC. 2009. Variation in the ovarian reserve is linked to alterations in intrafollicular estradiol production and ovarian biomarkers of follicular differentiation and oocyte quality in cattle. Biology of Reproduction 80(5):954-964.
• Ireland, JL; Scheetz, D; Jimenez-Krassel, F; Themmen, AP; Ward, F; Lonergan, P; Smith, GW; Perez, GI; Evans, AC; Ireland, JJ. 2008. Antral follicle count reliably predicts number of morphologically healthy oocytes and follicles in ovaries of young adult cattle. Biology of Reproduction 79(6):1219-1225.
• Jimenez-Krassel, F; Scheetz, DM; Neuder, LM; Ireland, JL; Pursley, JR; Smith, GW; Tempelman, RJ; Ferris, T; Roudebush, WE; Mossa, F; Lonergan, P; Evans, AC; Ireland, JJ. 2015. Concentration of anti-Müllerian hormone in dairy heifers is positively associated with productive herd life. Journal of Dairy Science 98(5):3036-3045.
• Koizumi, M; Kadokawa, H. 2017. Positive correlations of age and parity with plasma anti-Müllerian hormone concentrations in Japanese Black cows. The Journal of Reproduction and Development 63(2):205-209.
• Liang, A; Salzano, A; D’Esposito, M; Comin, A; Montillo, M; Yang, L; Campanile, G; Gasparrini, B. 2016. Anti-Mullerian hormone (AMH) concentration in follicular fluid and mRNA expression of AMH receptor type II and LH receptor in granulosa cells as predictive markers of good buffalo (Bubalus bubalis) donors. Theriogenology. 86(4):963-970.
• Monniaux, D; Barbey, S; Rico, C; Fabre, S; Gallard, Y; Larroque, H. 2010. Anti-Müllerian hormone: a predictive marker of embryo production in cattle? Reproduction, Fertility and Development 22(7):1083-1091.
• Monniaux, D; Di Clemente, N; Touzé, Jl; Belville, C; Rico, C; Bontoux, M; Picard, JY; Fabre, S. 2008. Intrafollicular steroids and Anti-Müllerian hormone during normal and cystic ovarian follicular development in the cow. Biology of Reproduction 79(2):387-396.
• Monniaux, D; Drouilhet, L; Rico, C; Estienne, A; Jarrier, P; Touzé, J; Sapa,J; Phocas, F; Dupont, J; Dalbiès-Tran, R; Fabre, S. 2012. Regulation of anti-Mullerian hormone production in domestic animals. Reproduction, Fertility and Development 25(1):1-16.
• Mossa, F; Jimenez-Krassel, F; Folger, JK; Ireland, JL; Smith, GW; Lonergan, P; Evans, AC; Ireland, JJ. 2010. Evidence that high variation in antral follicle count during follicular waves is linked to alterations in ovarian androgen production in cattle. Reproduction 140(5):713-720
• Pfeiffer, KE; Jury, LJ; Larson, JE. 2014. Determination of anti-Müllerian hormone at estrus during a synchronized and a natural bovine estrous cycle. Domestic Animal Endocrinology 46:58-64.
• Ribeiro, ES; Bisinotto, RS; Lima, FS; Greco, LF; Morrison, A; Kumar, A; Thatcher, WW; Santos, JE. 2014. Plasma anti-Müllerian hormone in adult dairy cows and associations with fertility. Journal of Dairy Science 97(11):6888-6900
• Rico, C; Drouilhet, L; Salvetti, P; Dalbiès-Tran, R; Jarrier, P; Touzé, JL; Pillet, E; Ponsart, C; Fabre, S; Monniaux, D. 2012. Determination of anti-Müllerian hormone concentrations in blood as a tool to select Holstein donor cows for embryo production: from the laboratory to the farm. Reproduction, Fertility and Development 24(7):932-944.
• Rico, C; Fabre, S; Médigue, C; di Clemente, N; Clément, F; Bontoux, M; Touzé, JL; Dupont, M; Briant, E; Rémy, B; Beckers, JF; Monniaux, D. 2009. Anti-Müllerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow. Biology of Reproduction 80(1):50-59.
• Rico, C; Médigue, C; Fabre, S; Jarrier, P; Bontoux, M; Clément, F; Monniaux, D. 2011. Regulation of anti-Müllerian hormone production in the cow: a multiscale study at endocrine, ovarian, follicular, and granulosa cell levels. Biology of Reproduction 84(3):560-571.
• Rojas-García, PP; Recabarren, MP; Palma, S; Maliqueo, M; Carrasco, A; Sir-Petermann, T; Recabarren, SE. 2014. Morfometría ovárica y expresión del ARN mensajero de hormona antimülleriana (AMH), receptor de FSH (FSHR) y factor nuclear kappa B (NFkB) en folículos en crecimiento de borregas expuestas prenatalmente a testosterona. Archivos de Medicina Veterinaria 46(1):13-21.
• Santa Cruz, R; Cushman, RA; Viñoles, C. 2018. Antral follicular count is a tool that may allow the selection of more precocious Bradford heifers at weaning. Theriogenology 119:35-42.
Publicado
2019-06-30
Cómo citar
Macias Andrade, J., Vivanco Mackie, H., Hurtado, E. A., & Carreño Mendoza, Ángela. (2019). Niveles plasmáticos de la hormona antimülleriana y su relación con la población folicular en hembras Brahman. Zootecnia Tropical, 37(1-2), 25 - 34. Recuperado a partir de http://publicaciones.inia.gob.ve/index.php/zootecniatropical/article/view/380
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Artículo de investigación
Derechos de autor 2019 Jorge Macias Andrade, Henry Vivanco Mackie, Ernesto A. Hurtado, Ángela Carreño Mendoza
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0.
